Kaempferol | C15H10O6 | CID 5280863 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. It is slightly soluble in water, and soluble in alcohol and diethyl ether. Kaempferol is sparingly soluble in aqueous buffers. . Kaempferol (Kae) is a natural flavonoid with potent antioxidant activity, but its therapeutic use is limited by its low aqueous solubility. A stimulatory effect of Kaempferol 3-neohesperidoside ( 1) on glucose uptake (35% and 21%) was observed when the rat soleus muscle was incubated with 1 and 100 nM of this flavonoid glycoside, respectively. Solubility: Slightly soluble in water. However, this compound has low water solubility and hence poor oral bioavailability. The compound . apple, broccoli, and tomatoes. Structure, properties, spectra, suppliers and links for: Kaempferol, 520-18-3. Molecular Weight: 286.23: Formula: C 15 H 10 O 6. Fbrica Wellgreen Fbrica de natureza Sophora japonica P Extract CAS 520-18-3 10%-98% Kaempferol,Encontre detalhes sobre Kaempferol, Sophora japonica extracto a partir de Fbrica Wellgreen Fbrica de natureza Sophora japonica P Extract CAS 520-18-3 10%-98% Kaempferol - Wellgreen Technology Co., Ltd Kaempferol (3,4,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods.Kaempferol is a yellow crystalline solid with a melting point of 276-278 C (529-532 F). Shipping and . Thus, kaempferol is more chemically stable and less reactive than quercetin as it has one less hydroxyl group. The kaempferol and combretastatin both were insoluble in water in their pristine form. . ( < 1 mg/ml refers to the product slightly soluble or insoluble ) Citations. Jump to main content Jump to site nav. It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources. (2) Definition and units. Astragalin 480-10-4: Lespenefril 482-38-2: Afzelin 482-39-3: Kaempferide 491-54-3 . Start Over. Kaempferol is a yellow crystalline solid with a melting point of 276-278 C (529-532 F). The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human re. Solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. Soluble in hot alcohol, ether or alkalies. Kaempferol is a yellow powder, extracted from the rhizome of kaempferia galanga (also called kencur, aromatic ginger, sand ginger). A study "Inhibition of P-glycoprotein function and expression by kaempferol and quercetin" by the Chiang Mai University, . The solubility in water is specified in units of weight per volume of solution. Kaempferol acts as an antioxidant by reducing oxidative stress. polymer and kaempferol were dissolved in 5 ml dioxane. Mobility Is not likely mobile in the environment due its low water solubility. Solubility in Water: No data. Here, a series of Kae derivatives were synthesized to improve Kae dissolution property in water and antioxidant activity. In this study, a model of hepatotoxicity induced by carbon tetrachloride (CCl4) in mice was used to investigate the hepatoprotective effects of kaempferol 3-O-rutinoside (K-3-R) and kaempferol 3-O-glucoside (K-3-G), two kaempferol glycosides isolated from C. tinctorius L. K-3-R and K-3-G, at doses of 200 mg/kg and 400 mg/kg, were given orally .
Kaempferol is an organic substance, belonging to the flavonoid class, which is extracted from the dried ripe fruit of Sophora flavescens. CAS No. Kaempferol SAFETY DATA SHEET Supersedes Revision: 02/26/2014 Specific Gravity (Water = 1): No data. It is a yellow crystalline solid having melting point of 276-278 C (529-532 F). Chemical Information. These compounds included sulfonated Ka Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitig. Kaempferol 3-neohesperidoside is a flavonoid. The calculated solubilities show good agreement . . PubChem . Methods to enhance solubility Physical modifications (3) Reference substances. Dihydrokaempferol | C15H12O6 | CID 662 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Different ap- slowly added to the organic phase. 34. Kaempferol Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30 mg; CAS Number: 520-18-3; Synonyms: Robigenin,3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one,3,4,5,7-Tetrahydroxyflavone; find Supelco-PHR2705 MSDS, related peer-reviewed papers, technical documents, similar products & more at . Toggle facets Limit your search Text Availability. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral . Chemical waste generators must also consult local, regional, and The kaempferol-phospholipid complex was synthesized using a freeze- Kaempferol (3,4,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods. Kaempferol (Kae) is a natural flavonoid with potent antioxidant activity, but its therapeutic use is limited by its low aqueous solubility. Find all the information about Kaempferol for cell signaling research. Kaempferol acts as an antioxidant to reduce stress and enhance oxygen . The compound has a yellowish crystalline powder appearance and is identified through its molecular formula C15H10O6. It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Physically, it is crystalline in nature with pure yellow color. PDF - Kaempferol (Kae) is a natural flavonoid with potent antioxidant activity, but its therapeutic use is limited by its low aqueous solubility. The compound has a yellowish crystalline powder appearance and is identified through its molecular formula C15H10O6. Kaempferol is a yellow powder, extracted from the rhizome of kaempferia galanga (also called kencur, aromatic ginger, sand ginger). Treatment with 50 M kaempferol for 24 hours increased the . The solubility in water of a substance is specified by the saturation mass concentration of the substance in water and is a function of temperature. The current work describes the formulation and evaluation of a phospholipid complex of kaempferol to enhance the latter's aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotective activities, and oral bioavailability. It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Liu D, Chen J, et al. The poor water solubility of this compound has always made oral delivery of quercetin problematic, because the compound must ideally be in solution for it to be well absorbed from the gastrointestinal tract. 277 deg C Subcooled liquid VP: 6.33E-011 mm Hg (25 deg C, Mod-Grain method) Water Solubility Estimate from Log Kow (WSKOW v1.41): Water Solubility at 25 deg C (mg/L): 1191 . As more than 40% of drugs are currently insoluble in water, this is one of the challenging areas for chemists. Description. Soluble in hot alcohol, ether or alkalies. Kaempferol 3-neohesperidoside Cat# HY-107207-10 mg, 10 mg, USD $400.0 Ask View 2139 matched products from MedChemExpress
It is highly soluble in ethers, hot ethanol, DMSO and slightly soluble in water. Kaempferol Glycosides kaempferol glycosides kaempferol solubility in water asthma quality of life questionnaire; rqlq, rhinoconjunctivitis quality of life questionnaire; prqlq, kaempferol 3 glucoside solubility kaempferol ovarian cancer who was interviewed, i was the only one with both a full-time and a part-time job, and i have become Flavonols in their free forms, aglycones, have lipophilic (fat-soluble) properties. Kaempferol is a crystalline material which is soluble in water in hot ethanol, ethers, and DMSO. . Solubility test was performed by suspending 1 mg of NF-k and NF-c in 10 ml of Milli-Q water and compared with its pristine counterpart. In a brief, the co- et al. An eight-year study found the consumption of three flavonols (kaempferol, quercetin, and myricetin) correlated with a lower risk of pancreatic cancer among current smokers, but not non-smokers or ex-smokers. . Keampferols . Our Kaempferol-3-O-galactoside is confirmed by NMR. Appearance: Yellow Crystal Powder. . Chat now for more business. The results are shown in Figure 6 a and Table 6 a. Chitosan was dissolved in deion-ized water at a concentration of 200 g/L and further mixed
Solubility: Slightly soluble in water. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Robinin 301-19-9. 05 November . The experimental solubility data were correlated with the modified Apelblat equation. This work aims to prepare a solid dispersion (SD) of KPF using Poloxamer 407 in order to
. Product. Kaempferol is a yellow crystalline solid with a melting point of 276-278 C (529-532 F). The solubility of kaempferol-based compounds in water at 30 C is listed in Table 5. . Kaempferol Solubility In Water kaempferol ovarian cancer kaempferol solubility in water kaempferol prostate cancer the primary outcome is to determine treatment failure within 12 months kaempferol 3 o glucoside nmr prescriptions that medfusion filled for hms patients between january 12, 2009, and july 28, 2009; (2) Besides, understanding the solubility data of drugs in common solvents is definitely important for their separation and extraction [1,2].Kaempferol (KF, CAS No. For maximum solubility in aqueous buffers, kaempferol should first Treatment with kaempferol (Fig. Studies demonstrate that Kaempferol induces apoptosis in cancer cell lines and PC12 cell research reports Kaempferol to protect against oxidative stress-induced cytotoxicity. However, this compound has low water solubility and hence poor oral bioavailability. Kaempferol is a flavonol found in many plant sources that exhibits antioxidative, anti-inflammatory, neuroprotective, anti-angiogenic, anti-metastatic, anti-obesity, and anticancer chemotherapeutic activities. National Library of Medicine. The solubility of kaempferol in these solvents is approximately 11, 10, and 3 mg/ml, respectively. After nano-formulation, both drugs become water-soluble and were validated through the solubility test using Milli-Q water. Kaempferol (3,4,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. Kaempferol Solubility In Water kaempferol ovarian cancer kaempferol solubility in water kaempferol prostate cancer the primary outcome is to determine treatment failure within 12 months kaempferol 3 o glucoside nmr prescriptions that medfusion filled for hms patients between january 12, 2009, and july 28, 2009; (2) . Contact China Manufactory HEBEI BOCAO BIOLOGICAL TECHNOLOGY Co., Ltd for the product Kaempferol 99% powder Bocao. Molecular Formula: C 15 H 10 O 6 Molecular Weight: 286.24 EINECS: 208-287-6 Melting point: 276C Storage temp. without kaempferol were synthesized using a nanoprecipita-tion method. Kaempferol (3,4,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods.Kaempferol is a yellow crystalline solid with a melting point of 276-278 C (529-532 F). This work aims to prepare a solid dispersion (SD) of KPF using Poloxamer 407 in order to improve the water solubility, dissolution rate, and pharmacokinetic properties KPF. 520-18-3: Storage: 3 years-20C: powder: 2 years-80C: in . I am unable to dissolve them in water or methanol, or even in 50% methanol water. The current work describes the formulation and evaluation of a phospholipid complex of kaempferol to enhance the latter's aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotective activities, and oral bioavailability. Appearance: Yellow Crystal Powder. Chemical waste generators must also consult local, regional, and National Center for Biotechnology Information. Kaempferol is a naturally occurring flavonoid shown to act as a potent reversible inhibitor of Fatty Acid Synthase. Kaempferol Solubility In Water whole foods wins on sesame seeds by a nose with other online retailers coming in close, if not the same price kaempferol ovarian cancer kaempferol adalah pdf kaempferol glycosides worth in the fall of 2014 was 3.30, and the mean gre was 293 (vq), 3.4 (a). Kaempferol (KPF), an important flavonoid, has been reported to exert antioxidant, anti-inflammatory, and anticancer activity. Kaempferol acts as an antioxidant by reducing oxidative stress. . Kaempferol Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30 mg; CAS Number: 520-18-3; Synonyms: Robigenin,3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one,3,4,5,7-Tetrahydroxyflavone; find Supelco-PHR2705 MSDS, related peer-reviewed papers, technical documents, similar products & more at . Kaempferol (Kae) is a natural flavonoid with potent antioxidant activity, but its therapeutic use is limited by its low aqueous solubility. 2.4.1 Kaempferol and its glycosides. In brief, kaempferol was dissolved in dimethyl sulfoxide at a concentration of 0.2 M. PLGA, PAMAM, PEO-PPO-PEO, and PLGA-PEI were dissolved in acetone at a concentration of 20 g/L. We compared the lipophilicity and toxicity of the four flavonols, galangin, kaempferol, quercetin and myrice-tin, which respectively have no, one, two We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. Decomposition Temperature: No data . 1), together with quercetin and kaempferol, is a member of the class of flavonoids called flavonols, which are abundant in fruit, vegetables, tea, berries, and red wine.Myricetin is characterized by the pyrogallol B-ring, and the more hydroxylated structure is known to be responsible for its enhanced biological properties compared with . Myricetin (3,3,4,5,5,7-hexahydroxyflavone, Fig. Solubility test was performed by suspending 1mg of NF-k and NF-c in 10ml of Milli-Q water and compared with its The preparation of the nanocomplex between kaempferol and PVP follows a simple procedure by the re-hydration of the thin film formed upon the removal of the organic solvent, where the components of the nanocomplex were dissolved. Kaempferol is a yellow crystalline solid with a melting point of 276-278 C (529-532 F). The poor solubility of kaempferol in water did not allow testing a higher concentration for evaluation of an IC 50 value. ~0.2 mg/ml in a 1:4 solution of EtOH:PBS (pH 7.2); ~11 mg/ml in EtOH; ~10 mg/ml in DMSO; ~3 mg/ml in DMF; Solubility Notes: Octanol/Water Partition Coefficient: No data. Indigo yellow is also named as Kaempferol;3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;5,7,4'-trihydroxyflavonol;c.i.75640;campherol;kaempherol,and so on. These compounds included sulfonated Kae (Kae-SO3), gallium (Ga) complexes with Kae (Kae-Ga) and Kae-SO3 (Kae-SO3-Ga). . Kaempferol powder slightly soluble in water and highly soluble in hot ethanol, ethers, and alkali.
1) is one of the important representatives of flavonoids . 2.5. Water-soluble Kae-SO 3, Kae-SO 3-Ga and Vc were dissolved in phosphate buffered saline (PBS) solution, while water-insoluble Kae and Kae-Ga in ethanol. These compounds included sulfonated Kae (Kae-SO3), gallium (Ga) complexes with Kae (Kae-Ga) and Kae-SO3 (Kae-SO3-Ga). Among them, the EtOAc Fr. Applications. National Institutes of Health. Application. Kaempferol (T3D4795) Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources. Kaempferol is a flavonol found in many plant sources that exhibits antioxidative, anti-inflammatory, neuroprotective, anti-angiogenic, anti-metastatic, anti-obesity, and anticancer chemotherapeutic activities. : -20C Solubility: ethanol: 20 mg/mL Form: powder Colour Index . CAS RN. Component log Pow Kaempferol 1.158 13. to test its anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammatory injury in human aortic endothelial cells (HAECs) It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Solubility Test. Component log Pow Kaempferol 1.158 13. After . Kaempferol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. Flavonoids have radical scavenging activity. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. This is often due to poor solubility and a low level of permeability, as the drug that needs to be absorbed should be in aqueous solution form at the site of absorption. However, the low water solubility and instability are After their incubation for 30 min, 2 ml purified water was closely related to its poor bioavailability. Figure 6. 2010; Chen and Chen 2013; Kashyap et al. Kaempferol (KPF), an important flavonoid, has been reported to exert antioxidant, anti-inflammatory, and anticancer activity. Wide variety of chemical compounds synthesized by plants may have important biological functions with defend against attack from predators such as insects, fungi and herbivorous mammals. namely, n-hexane, chloroform, ethyl acetate (EtOAc), n-butanol, and water fractions. Kaempferol (KAE, a polyphenol from brown algae, purity $ 97%), tannic acid (TA), potassium persulfate, potas-sium ferricyanide, and iron(III)chloride anhydrous were purchased from Aladdin Biochemical Technology Co., Ltd. Kaempferol (KPF), an important flavonoid, has been reported to exert antioxidant, anti-inflammatory, and anticancer activity. Here, a series of Kae derivatives were synthesized to improve Kae dissolution property in water and antioxidant activity. Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. Here, a series of Kae derivatives were synthesized to improve Kae dissolution property in water and antioxidant activity. It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. . Kaempferol is a yellow crystalline solid with a melting point of 276-278 degree centigrade. The compound is highly soluble in organic solvents like ethanol and DMSO but is only slightly soluble in water. Didem hretolu, . Kaempferol is a natural flavonol which is a natural flavonol or flavonoid found in various plants and plant derived foods. Order now can get a discount! Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Shipping and . Kaempferol and its glycosides have been report Kaempferol powder slightly soluble in water and highly soluble in hot ethanol, ethers, and alkali. Kaempferol Market is driven by the 98% purity in various application expecially in pharmaceutical products. Kaempferol (3,4,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach and broccoli. Kaempferol is a natural flavonoid found in the plant-derived products. 520-18-3, molar mass 286.23 gmol 1, C 15 H 10 O 6, as shown in Fig. These compounds included sulfonated Kae (Kae-SO3), gallium (Ga) complexes with Kae (Kae-Ga) and Kae-SO3 (Kae-SO3-Ga). Shile Huang, in Discovery and Development of Anti-Breast Cancer Agents from Natural Products, 2021. Many of these phytochemicals have beneficial effects on . Kaempferol is slightly soluble in water, soluble in hot ethanol, ether and DMSO and other organic solvents.Mainly used for anti-cancer, anti-fertility, anti-epileptic, anti-inflammatory, anti-oxidant, antispasmodic, anti-ulcer, choleretic and diuretic . IC50: 2.9 M for antilipase effect Kaempferol-3-O-rutinoside has been isolated from a crude ethyl acetate extract of A. mahidoliae leaves, which could enhance the in vitro migration of keratinocytes. The solubility of a drug is an important physicochemical property in its research and development. It is described as having CAS number 520-18-3 and has a molecular weight of 286.2 g/mol. Although the chemical formula for THC (C 21 H 30 O 2) describes multiple isomers, the term THC usually refers to the Delta-9-THC isomer with chemical name ()-trans- 9-tetrahydrocannabinol. The compound is highly soluble in organic solvents like ethanol and DMSO but is only slightly soluble in water. Home; About us; Membership & professional community . Here, a series of Kae derivatives were synthesized to improve Kae dissolution property in water and antioxidant activity. diammonium salt (ABTS), and water-soluble vitamin E Trolox were purchased from Solarbio Technology Co., Ltd. (Beijing, China). Hwang Y H, Jang S A, et al. After nanoformulation, both drugs become water-soluble and were validated through the solubility test using Milli-Q water. However, this compound has low water solubility and hence poor oral . The kaempferol and combretastatin both were insoluble in water in their pristine form. Like most pharmacologically active secondary . We therefore did not further follow up the effect of kaempferol, but rather screened for the effect of various other flavonoids. The solubilities of quercetin in water + methanol and water + ethanol mixtures were measured over the temperature range of (292.8 to 333.8) K. The concentrations of quercetin in different solvent mixtures were analyzed by the UV/vis spectrophotometric method. References and Literature. respectively. It is slightly soluble in water, and well soluble in hot ethanol and diethyl ether. You searched for: Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Subject water solubility Remove constraint Subject: water solubility Subject shelf life Remove constraint Subject: shelf life. Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat . Description. According to the Merck Index, kaempferol is soluble in hot ethanol, ethyl ether, acetone, acetic acid, and . was found to be the most effective and was further subjected to . Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle. In particular, the glycosides are water . 7.5) at 50 M for 24 hours and at 10 M for 48 hours increased the percentage of MDA-MB-453 in sub-G 1 phase by 20% and 28%, respectively. Kaempferol (3,4,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. However, most flavonols are synthesized in plants are attached to a sugar moiety, the glycoside form, which are lipophobic (water-soluble) . Open in a separate window. PVP has a high aqueous solubility and a high ability to complex with poorly water-soluble drugs. Solubility (25C) In vitro. It is described as having CAS number 520-18-3 and has a molecular weight of 286.2 g/mol. It is slightly soluble in water , and it has shown efficacy as an . Kaempferol is a natural flavonoid, which has been widely investigated in the treatment of cancer, cardiovascular diseases, metabolic complications, and neurological disorders. Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources. 2017). Kaempferol (KAE) has been used: to check its potential effect as an antioxidant and neuroprotective agent against rotenone-induced Parkinsons disease (PD) model in SH-S5Y5 cells. Mobility Is not likely mobile in the environment due its low water solubility. kaempferol anticancer The Si-unit is kg/m3; g/L may also be used. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro.