Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography Optical coherence tomographic angiography (OCTA) is a novel technology capable of imaging retinal vasculature three-dimensionally at capillary scale without the need to inject any extrinsic dye contrast. For the POAG group, significant changes occurred in the radial peripapillary capillary plexus (RPCP) and in the SCP, which correlated with peripapillary RNFL thickness reduction. Three layers of concentrated capillary density could be seen in the retina (top layers of upper image): superior vascular complex, intermediate capillary plexus, and deep capillary plexus. Photo: Erin Jenewein, OD. Therefore, retinal vessels may also be affected by PDT and should be analyzed in this manner. 56 These OCTA findings suggest notable patterns of vessel attenuation in the retina that may be used to discern between AD and POAG. Figure 1. Localized retinal capillary ischemia at the level of intermediate plexus is proposed as the mechanism underlying the development of these lesions. capillary beds could lead to a larger area of vascular network visualized per unit area of the peripapillary retina; however, these capillary beds may be dysfunctional. PAMM is an SD-OCT abnormality that may herald the presence of a secondary underlying condition predisposing to microvascular ischemic injury. mentation into the SCP, deep retinal capillary plexuses (DCP), outer retina, and the choroid capillary. PAMM is thought to be a reflection of intraretinal ischemia predominantly of the intermediate and deep retinal capillary plexuses located in the inner nuclear layer (INL). Iuliano L, Fogliato G, Colombo R, Sacconi R, Querques G, Bandello F and Codenotti M (2019) Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction, BMC Ophthalmology, 10.1186/s12886-019-1119-9, 19:1, Online publication date: 1-Dec-2019. Association of Retinal Capillary Plexus and Ganglion Cell Complex With Cognitive Impairment We show the unadjusted and adjusted ORs of the RCP and GCC for cognitive impairment in Table 3. The ischemic etiology of disease is supported by OCT-A findings of decreased blood flow and abnormal vasculature in the deep capillary plexus (DCP) of PAMM lesions [8,9]. Here we report the clear delineation of capillary dropout in the deep capillary plexus using optical coherence tomography angiography (OCTA) in a chronic case of unexplained scotoma that developed after femoral fracture. This slab captures the superficial capillary plexus of the retina and, often, part of the radial peripapillary capillary plexus. Therefore, retinal capillary dropout is a very important feature observed by OCTA in the early stages of DR. Furthermore, a radial peripapillary capillary plexus has been shown to run parallel to nerve fiber layer axons that exit the eye via the optic disc 10. To assess retinal sensitivity and retinal morphologic changes of capillary nonperfused areas in diabetic macular ischemia. Disease Entity Paracentral Acute Middle Maculopathy. C-scan wide-field montages of the three capillary plexuses. On the basis of these findings, a final diagnosis of paracentral acute middle maculopathy secondary to Purtscher's retinopathy was made. The SVC is subdivided into the retinal peripapillary capillary plexus (RPCP) and the superficial vascular plexus (SVP). Cystoid macular edema is evident on the structural OCT B scan and en face images. Idiopathic epiretinal membrane (ERM) is a frequently diagnosed macular pathology characterised by fibrocellular proliferation on the inner retinal surface.1 Despite the anatomical restoration after ERM removal, some patients continue to have persistent symptoms; thus, the identification of predictors of postoperative visual outcomes continues to be an urgent quest.2 Preoperative . Variable recovery of capillary flow signal is noted with time in the deep capillary plexus. Capillary loss was mild in the superficial capillary plexus (Fig. Methods . The metabolic slowdown is defined as a dormant phase in photoreceptors and OFF mode in the neural retina. Primary prevention. PAMM occurs as an isolated phenomenon or as complicating feature of an underlying retinal vasculopathy or systemic disease. Purpose . Introduction. Visualizing the ICP, SVP, and DCP with OCTA could significantly improve our understanding of retinal diseases, including diabetic retinopathy, macula telangiectasia, and paracentral acute middle .

None. Fourteen consecutive diabetic eyes showing outer retinal changes on spectral domain optical coherence tomography B-scan were included. Image artifacts Capillary plexus projections are slightly offset compared to the corresponding retinal layers on structural OCT. All structural B-scans, and B-scans with flow overlay were scrolled and controlled by two experts for the correctness of automated layer segmentation, the absence of intraretinal cysts, as well as for foveal avascular zone (FAZ . Identifying Peripapillary Radial Capillary Plexus Alterations in Parkinson's Disease Using OCT Angiography. The retinal deep capillary plexus is a single monoplanar capillary plexus located in the OPL. 1 it describes the anatomic lack of a foveal pit, which can be associated with variable visual acuity.1 fovea plana occurs secondary to disruption of the development of the fovea and has been reported in cases of ocular albinism and in conjunction with pax6 gene mutations. The retinal (6 6 mm) and optic disc (4.5 4.5 mm) OCTA images were evaluated for superficial capillary plexus (SCP), deep capillary plexus (DCP) and radial peripapillary capillary plexus (RPCP). BackgroundTo determine the association between serum uric acid (SUA) and the retinal capillary plexus (RCP) using optical coherence tomography angiography (OCTA).MethodsThis cross-sectional study evaluated data from August 2019 to January 2020 from participants recruited from the Jidong community (Tangshan, Hebei, China). Design Prospective observational cross-sectional study. Intermediate capillary plexus and deep capillary plexus changes were strongly correlated (r = 0. Measure-ments of SCP vessel density on en-face projections were analyzed. previous research suggested that the deep capillary plexus might be the primary site of venous outflow for the entire retinal microvasculature, leading the researchers of this current study to believe that "the physiologic differences in structure and function between the [superficial] and [deep plexuses] might cause them to be affected The retinal capillary microaneurysm is a hallmark feature of microvascular disease in diabetic retinopathy (DR) (1-5).It represents a focal insult to the retinal microcirculation and can demonstrate morphologic progression with time (6,7).Despite detailed ultrastructural and histologic studies (4,8), the disease pathways that underlie the heterogeneous structural and functional properties of . Patients were examined at IRCCSBietti Foundation, Rome, Italy.

The retinal (6 6 mm) and optic disc (4.5 4.5 mm) OCTA images were evaluated for superficial capillary plexus (SCP), deep capillary plexus (DCP) and radial peripapillary capillary plexus . One layer of high capillary density is seen in the choriocapillaris (bottom layer). The yearly increase in FAZ area was 0.003 mm (P < 0.001). 4c, d). 3 3-mm C-scan montage of the superficial vascular plexus (SVP, top left), intermediate capillary plexus (ICP, top right) and deep . Diagnosis Methods: We enrolled 167 consecutive children with T1D. The retinal capillary vasculature serves the formidable role of supplying the metabolically active inner and middle retina. OCT-A reveals reduced flow signals in deep retinal capillary plexus, suggesting focal ischemia photoreceptor axons in the outer plexiform layer. The periarterial capillary-free zone (paCFZ) areas, artery areas and paCFZ area to artery area (P/A) ratio of the first-order (a-c) and second-order (d-f) arteries in the unaffected quadrants of branch retinal vein occlusion (BRVO) eyes at baseline and 3, 6 and 12 months after intravitreal ranibizumab (IVR) injections.Before treatment, the BRVO eyes demonstrated significantly larger paCFZ .

The vessel densities (in %) of deep capillary plexus were measured with "AngioAnalytic" feature of the OCTA device. The metabolic slowdown is defined as a dormant phase in photoreceptors and OFF mode in the neural retina. Outer retina is mainly supplied by CCP in the choroid layer. Plexus Changes sentence examples within Capillary Plexus Changes. The vascular reserve can be interpreted, which may be useful in management decisions. Paracentral acute middle maculopathy (PAMM) is an optical coherence tomography finding seen in patients with retinal capillary ischemia and unspecific persistent scotomas. Optical coherence tomography angiography (OCTA) enables closer observation of the blood flow of each retinal capillary layer.8 Recent studies using OCTA demonstrated that deep capillary plexus (DCP) of the long-standing large MH is compromised,9 and the foveal avascular zone (FAZ) area of superficial capillary plexus (SCP) was decreased after . The women's retinal vascular status was measured by OCT angiography at three time points: the early follicular, ovulatory and midluteal phases of the menstrual cycle. The superficial vascular plexus and intermediate capillary plexus were not affected (I). Vascular density decreased with age in the three capillary plexuses. Deep retinal capillary vessel density [ Time Frame: Change from baseline deep reinal capillary vessel density at 1 month. ] After surgery, the patients completed an eye exam within 1 week, at 1 month, and at 6 months. 7 The studies discussed in this article use these terms and therefore required clarification. A decrease of FD, VPD and VLD in either SCP or DCP appeared with an increased risk of moderate/severe WMHs. OCT-A Can Assess Retinal Perfusion in Children With Amblyopia Macular vessel density of the superficial capillary plexus is lower among these patients. Retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density data underwent analysis. This slab is important in retinal vascular diseases where drop out or malformation of the microvasculature can be seen. Conversely, in the deep plexus, capillary nonperfusion areas were seen only in 35% (7/20) of eyes, whereas DR led to an alteration of the normal capillary vortex pattern in all eyes. The deep capillary plexus, a single monoplanar capillary plexus located in the outer plexiform layer, has the lowest VD, a significant finding that might be used to evaluate retinal vascular diseases. While there was progression of the retinal atrophy after 6 months ( J - L ), especially of the inner nuclear layer and outer plexiform layer (orange arrows in J and L , there was no progression of the perfusion defects on optical coherence tomography . It has the lowest vessel density-this is a signicant nding that might be used to evaluate retinal vascular diseases accurately. It appears in cross-sectional optical coherence tomography (OCT) B-scans as a hyper-reflective band involving the inner nuclear layer (INL) [ 3, 4, 5 ]. Methods Subjects were divided into three groups: the control group (98 eyes), patients with T2DM < 10 years (DM group 1, 84 eyes), and patients with T2DM 10 years (DM group 2, 55 eyes). For this . . Objective To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA). However whole area, parafoveal and perifoveal vessel . Its formation is based on 10, oxygen saturation during embryonic development All participants completed detailed anthropometrical measurements . Deep capillary plexus vessel density may predict visual recovery following successful rhegmatogenous retinal detachment surgery, according to a report. For this . the parameters used to identify the location of each retinal capillary plexus were: 1) the minimal distance of 9 m between capillary plexuses, meaning that if two plexuses were closer than 9 m to. . The relationship between retinal blood flow and amblyopia has not yet been made clear. Photo: Erin Jenewein, OD. Presented at: the 2020 North Carolina Society for Eye Physicians and Surgeons Annual Meeting, Greensboro, North Carolina, September 19, 2020. Observational cross-sectional study.

The retinal capillary microaneurysm is a hallmark feature of microvascular disease in diabetic retinopathy (DR) (1-5).It represents a focal insult to the retinal microcirculation and can demonstrate morphologic progression with time (6,7).Despite detailed ultrastructural and histologic studies (4,8), the disease pathways that underlie the heterogeneous structural and functional properties of . Purpose To identify the effects of prolonged type 2 diabetes (T2DM) on the retinal microvasculature of each retinal capillary plexus in patients without clinical diabetic retinopathy (DR). The branches from the central retinal circulation form two distinct capillary plexi within the ganglion cell layer (the superficial capillary plexus) and in the inner nuclear layer (the deep capillary plexus). . Normal OCT angiogram showing the segmentation of the retina into various slabs (Optovue AngioVue). The DCP only showed a slightly decreased CD towards the retinal periphery. Although changes of capillary plexus were not associated with paraventricular WMHs, decreased FD, VPD, VLD and fovea avascular zone area in either SCP or DCP were associated with an increased risk of moderate/severe deep WMHs (DWMHs). A recent study reported that, when compared with the fellow eye, the blood flow density of the macula and the surrounding retinal capillary network of . Using PR-OCTA, we recently demonstrated retinal vessel density signifi- 2, 3 The retinal periarterial 8 capillary-free zone (paCFZ), first described by His in 1880, is a physiologically avascular area surrounding the retinal arteries exclusively in the superficial cap-illary plexus layer [11]. Setting/Venue Tertiary referral university hospital, retrospective study Methods . The reference plane for the superficial plexus was defined as the inner limiting membrane (ILM) with an offset (from the interface reference) of 3 m to the

The adjusted OR with 95% CI for parafovea vessel density in deep RCP with cognitive impairment was 1.20 (1.03-1.39). Inner retina vasculature contains two different capillary plexuses: superficial capillary plexus (SCP) lies in the nerve fibre and ganglion cell layer, while deep capillary plexus (DCP) lies along the outer border of INL and OPL. OCTA in an eye with branch retinal vein occlusion showing irregular perifoveal tortuous vessels in the superficial and deep capillary plexus. Results Comparing vascular images acquired from OCTA and confocal microscopy, we found (1) a good representation of the larger caliber retinal vessels, (2) an underrepresentation of retinal microvessels smaller than 10 m and branch points in all four retinal vascular plexuses, particularly the intermediate capillary plexus, (3) reduced visibility associated with an increase in the angle of . To describe patterns of reperfusion in the superficial vascular plexus (SVP), deep capillary plexus (DCP) and choriocapillaris (CC) as detected on optical coherence tomography (OCTA) in . capillary beds could lead to a larger area of vascular network visualized per unit area of the peripapillary retina; however, these capillary beds may be dysfunctional. Methods The study included 14 eyes of 10 patients who were diagnosed as having diabetic retinopathy. Likewise, the DVC is divided into the intermediate capillary plexus (ICP) and DCP. By Staff OCT-A proves useful for the diagnosis and follow-up of children with amblyopia. In the parafoveal region, the retinal capillary plexuses (RCP) are organized in a system of three capillary layers of varying retinal depths: the superficial capillary plexus (SCP), intermediate capillary plexus (ICP) and deep capillary plexus (DCP). Background: This study aimed to assess the influence of pubertal status on the results of optical coherence tomography angiography (OCTA) in children with type 1 diabetes (T1D). The main outcome measures were foveal avascular zone parameters, and perfusion density in the superficial retinal capillary plexus as well as in the deep retinal capillary plexus. Purpose To evaluate anatomical changes in superficial capillary (SCP) and deep capillary (DCP) retinal plexuses, as well as choriocapillaris (CC) ischemia in DM patients without diabetic retinopathy (DR) or with mild and moderate DR without diabetic macular edema (DME) using Optical coherence tomography angiography (OCTA) (DRI-Triton SS-OCT). Additionally, cerebral MRI and cognitive function tests were performed. The retinal deep capillary plexus is a single monoplanar capillary plexus located in the OPL. The VDs of the macular region in the superficial retinal capillary plexus (SRCP), deep retinal capillary plexus (DRCP), and foveal avascular zone (FAZ) were determined, along with the VD of the optic nerve head (ONH) in the radial peripapillary capillary (RPC) network. Microperimetry map of the 3 3 area spanned with optical coherence tomography angiography (OCTA) in diabetic patients with various stages of superficial and deep capillary plexus impairment and retinal sensitivity reduction. This ICP disappearance resulted in an increased IPD between the SVP and the DCP in an area known to be frequently affected by capillary drop-out in diabetic retinopathy. The first case on the top of the image represents the normal control with no retinal sensitivity and no retinal . retinal plexuses described in histological studies: superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP).16-21 With this novel technology, it is now possible to evaluate the inner retinal circulation of eyes with AMD in vivo. It also delineates the foveal avascular zone. 4a, b) and more prominent in the deep retinal capillary plexus (Fig.